The Ohio Department of Transportation will close the eastbound lanes of Interstate 76 between Interstate 277/U.S. Route 224 and the Central Interchange from 7 p.m. Friday through 6 a.m. Monday.
The highway — which carries more than 100,000 vehicles each day — is being shut down so contractors can work on bridges and pavement striping.
In addition to the highway being closed, many ramps onto the highway will be closed.